1. Quick Detail:
Product name: Procaine HCl
Alias: Procaine hydrochloride;aminocaine;anadolor;atoxicocaine;
CAS register number: 51-05-8
Molecular formula: C13H21ClN2O2
Molecular weight: 272.77
Melting point: 155-156 °C
Storage: Shading, confined preservation
Appearance: White crystalline powder
Usage: Procaine hydrochloride is a kind of local anesthetics, for
local anesthesia, nerve block etc, can block the conduction of
nerve fibers with anesthetic effect, strong function, low toxicity,
and no addiction, but the skin, mucous membrane penetration force
is weak, not suitable for surface anesthesia, clinically used to
infiltration, spine and conduction anesthesia.
Procaine HCl is a local anesthetic drug of the amino ester group.
It is used primarily to reduce the pain of intramuscular injection
of penicillin, and it is also used in dentistry. Owing to the
ubiquity of the trade name Novocain, in some regions procaine is
referred to generically as novocaine. It acts mainly by being a
sodium channel blocker.Today it is used therapeutically in some
countries due to its sympatholytic, anti-inflammatory, perfusion
enhancing, and mood enhancing effects.
Procaine HCl is indicated for the production of local or regional
analgesia and anesthesia by local infiltration and peripheral nerve
Application of procaine leads to the depression of neuronal
activity. The depression causes the nervous system to become
hypersensitive producing restlessness and shaking, leading to minor
to severe convulsions. Studies on animals have shown the use of
procaine led to the increase of dopamine and serotonin levels in
the brain.Other issues may occur because of varying individual
tolerance to procaine dosage. Nervousness and dizziness can arise
from the excitation of the central nervous system, which may lead
to respiratory failure if overdosed. Procaine may also induce
weakening of the myocardium leading to cardiac arrest.
Procaine can also cause allergic reactions causing the individuals
to have problems with breathing, rashes, and swelling. Allergic
reactions to procaine are usually not in response to procaine
itself, but to its metabolite PABA. About one in 3000 people have
an atypical form of pseudocholinesterase, which
does not hydrolyze ester anesthetics such as procaine, resulting in
a prolonged period of high levels of the anesthetic in the blood
and increased toxicity.
|Product name||Procaine HCl|
|Appearance||White crystalline powder|
|Assay (C13H20N2O2·HCl)||99.0% to 101.0%||99.5%|
|Acidity||≤0.02N NaOH 0.5ml||0.3ml|
|Chromatographic purity||Secondary spots≤0.5%,sum≤1.0%||Conforms|
|Loss on drying||≤1.0%||0.06%|
|Residue on ignition||≤0.15%||0.03%|
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